Genetic interaction map could lead to better antibiotic pairings for tuberculosis
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Rockefeller scientists have created the most comprehensive map to date of how essential genes interact in Mycobacterium tuberculosis (Mtb), the bacterium responsible for tuberculosis (TB). The unprecedented map reveals thousands of previously unknown…
Scientists reveal how cosignaling receptors dually regulate T cell activation via phase separation
Comments Off on Scientists reveal how cosignaling receptors dually regulate T cell activation via phase separation
Previous studies have shown that upon antigen stimulation, the T cell receptor (TCR) undergoes phase separation with the kinase Lck to mediate rapid T cell activation. However, the manner in which costimulating receptors regulate this process has…